嵌合抗原受体修饰T细胞免疫疗法治疗B细胞恶性肿瘤患者的护理

摘要

In this paper,we summarized nursing care of 9 patients with cytokine release syndrome after receiving the chimeric antigen receptor T cells immunotherapy.Key points of nursing care were as follows:comfortable and effective antipyresis,preventive rehydration,multiple methods of blood oxygen saturation improvement,iatrogenic pressure ulcer prevention,frequent vital signs monitor,close observation of level of cytokine and inflammatory factors,timely and accurate medication,formulating personalized nursing plan according to patients' condition,close collaboration between doctors and nurses.At last,8 patients recovered and were discharged,and 1 case died due to multiple organ dysfunction syndrome.%总结了嵌合抗原受体修饰T细胞免疫疗法治疗B细胞恶性肿瘤患者的护理经验.护理要点包括:高热的护理,预防性补液,多途径提升血氧饱和度,预防医源性压疮,密切观察病情变化,严密监测细胞因子及炎性因子水平,按时准确给药,结合患者特殊病情制订个性化护理方案.8例治疗有效,好转出院,1例因多器官功能衰竭死亡.