加味四逆汤治疗慢性心力衰竭心肾阳虚证的临床效果观察

摘要

目的观察加味四逆汤治疗慢性心力衰竭心肾阳虚证的临床效果.方法选择2016-012017-02该院收治的慢性心力衰竭心肾阳虚证患者100例,按随机数字表法将其随机分为观察组和对照组,每组50例.对照组给予常规西药治疗,观察组在常规治疗基础上加用加味四逆汤治疗,连续治疗1个月为1个疗程,2个疗程后评估两组临床疗效及心功能、中医症候积分及药物不良反应发生情况.结果治疗2个疗程后,观察组临床疗效、心功能中的每搏输出量(SV)和左心射血分数(LVEF)较对照组高,而心功能中的左室收缩末径(LVSEd)和中医症候积分较对照组低,差异有统计学意义(P＜0.05);观察组药物不良反应率与对照组相比,差异无统计学意义(P＞0.05).结论加味四逆汤可提高慢性心力衰竭心肾阳虚证治疗效果,改善临床症状及心功能,且不良反应少,安全性高.%Objective To explore the clinical effect of Jiawei Sini decoction on heart-kidney yang deficiency syndrome of chronic heart failure.MethodsOne hundred patients with heart-kidney yang deficiency syndrome of chronic heart failure in our hospital from January 2016 to February 2017 were randomly divided into control group and observation group, with 50 cases in each group.The control group was given conventional western medicine treatment, and the observation group was given the same treatment as the control group plus Jiawei Sini decoction.Both of the two groups received treatment for two months (two courses of treatment).The clinical curative effect, cardiac function, Traditional Chinese Medicine (TCM) syndrome score and adverse drug reaction were compared between the two groups after treatment.Results After 2 courses of treatment, the total efficiency, SV and LVEF in the observation group were significantly higher than those in the control group.LVSEd and TCM syndrome scores in the observation group were significantly lower than those in the control group (P＜0.05).There was no significant difference in the adverse drug reaction rate between the two groups (P＞0.05).Conclusion Jiawei Sini decoction can improve the therapeutic effect of heart-kidney yang deficiency syndrome of chronic heart failure, improve the clinical symptoms and cardiac function, and cause less adverse reactions.