Objective To investigate clinical effects and adverse reactions of Kaihoujian sprays( child type) combined with Reduning injection in treating children with herpangina.Methods One hundred children with herpan-gina were divided into two groups.Fifty-five patients served as treatment group were given Reduning injection intrave-nously.Forty-five children regarded as the control group were given Watermelon frost sprays, which is widely used in local treatment and Ribavirin injection intravenously,for a full period of 5~7 days, and were given local kaihoujian sprays combined with conbi a supportive treatment according to the conditions of the disease.The observation indexes of the clinical efficacies and the clinical curative effect, and adverse reactions were compared between the two groups. Results The treatment group was 30 cases of significant effect, effective 20 cases, invalid in 5 cases;20 cases of control group were significant effect, 15 cases were effective, 10 cases ineffective, there was no statistically signifi-cant difference between the two groups in curative effect( P>0.05) .But defervescence time, mouth pain disappea-ring and Herpetic ulcer healing in treatment group was considerably better than the control group, the difference was statistically significant(P <0.01).The total number of white blood cells or the ratio of neutrophils decreased in 18 patients in the control group.There was no adverse reactions in treatment group.Conclusion Therapeutic effect of Kaihoujian sprays( child type) combined with Reduning injection in treating children with herpangina is significant, which is safety.%目的观察开喉剑喷雾剂（儿童型）联合热毒宁注射液治疗疱疹性咽峡炎的疗效及不良反应。方法将100例疱疹性咽峡炎患儿分为治疗组55例和对照组45例。治疗组给予开喉剑喷雾剂（儿童型）喷口腔疱疹局部治疗联合热毒宁注射液静脉滴注，对照组给予西瓜霜喷剂喷口腔疱疹局部治疗联合利巴韦林注射液静脉滴注，疗程5～7 d，并根据病情给予相应对症支持治疗。比较两组临床疗效及各项临床疗效观察指标和不良反应。结果治疗组显效30例，有效20例，无效5例；对照组显效20例，有效15例，无效10例，两组疗效差异无统计学意义（ P＞0.05）。但退热时间、口痛消失时间及疱疹溃疡消退时间，治疗组明显优于对照组，差异有统计学意义（ P均＜0.01）。对照组有18例出现白细胞总数减少或粒细胞比值下降，治疗组未见不良反应。结论开喉剑喷雾剂（儿童型）联合毒宁注射液治疗疱疹性咽峡炎疗效确切，安全性高，值得临床推广。
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