Objective To study the characteristic of pattern visual evoked potentials (P-VEP) in patients with type 2 diabetes and the relationship between the clinical factors and P-VEP. Methods In this study, 109 patients with type 2 diabetes were divided into three subgroups according to the disease duration, ＜5 years group, 5≤ course duration ＜10 years group. ≥10 years group. Patients and 40 healthy controls were analyzed retrospectively regarding clinical data, blood biochemicals, electromyography (EMG) and P-VEP changes. The results were analyzed by SPSS statistical software. Results The abnormal rate of P-VEP was 20. 00% in ＜5 years group (8 cases), 25. 81 % in 5 ≤course duration <10 years group (8 cases), and 36. 84% in 10 years group (14 cases), with the mean abnormal rate of 27. 52%. There was no statistically significant difference among the three diabetic groups (P＞0. 05). The amplitude was lower significantly in 5≤ course duration ＜10 years group and ≥10 years group compared with the control group (both P＞0. 05). There was no significant difference in the amplitude between the two groups (P＞0. 05). The latency of P100 was longer in ^ 10 years group significantly than that in the control group (P＜0. 05). There was no statistically significant difference of the P100 latency between the two groups (P＞0. 05). In the severe group (the number of diseased nerve＞4), the amplitude was lower significantly than that in the less serious group (the number/of diseased nerved 4) (P ＜0. 05). Non-conditional logistic regression analysis showed that course and glycosylated hemoglobin (HbALc) were the relevant factors of visual impairment in patients with type 2 diabetes. Conclusions P-VEP was a non-invasive method for the early detection of optic neuropathy in patients with type 2 diabetes. The course of disease and HbALc level were the relevant factors of visual impairment in patients with type 2 diabetes.%目的 探讨2型糖尿病患者视觉诱发电位(pattern visual evoked potential,P-VEP)改变的特点及其与各临床因素之间的关系.方法 对109例2型糖尿病患者及40例健康体检者进行P-VEP的检测,病例组按病程分为病程＜5年组、5年≤病程＜10年组、病程≥10年组.回顾性分析各组生化指标、肌电图等临床资料与P-VEP改变的相关性.应用SPSS统计软件进行统计学处理.结果 病例组P-VEP总异常率为27.52％,病程＜5年组P-VEP异常8例(20.00％),5年≤病程＜10年组P-VEP异常8例(25.81％),病程≥10年组P-VEP 异常14例(36.84％),各组间其异常率比较差异无统计学意义(P＞0.05).P100潜伏期的改变:病程≥10年组的P100潜伏期较对照组明显延长(P＜0.05),病程＜5年组、5年≤病程＜10年组的P100潜伏期较对照组无明显变化(P＞0.05).P100枕中波幅改变:5年≤病程＜10年组,病程≥10年组的枕中波幅较对照组明显降低(P ＜0.05),病程＜5年组的枕中波幅较对照组无明显变化(P＞0.05).周围神经病变严重组(病变神经数＞4条)的枕中波幅较周围神经病变较轻组(病变神经数≤4条)明显降低(P＜0.05).非条件Logistic逐步回归分析显示病程和糖化血红蛋白是2型糖尿病患者视力损害的相关因素.结论 P-VEP是早期发现2型糖尿病患者视神经病变的无创检测手段.病程和糖化血红蛋白是2型糖尿病患者视神经病变的相关因素.
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