侧脑室引流术在隐球菌性脑膜脑炎早期治疗中的应用

摘要

Objective To observe the clinical effect of the lateral ventricular drainage in early treatment of cryptococcal meningoencephalitis, and to investigate its efficacy and safety. Methods Retrospective review and analyse the clinical data of 5 patients who had cryptococcal meningoencephalitis with intracranial hypertension using above treatment. Results In all the 5 patients, clinical symptom alleviated rapidly after early lateral ventricular drainage treatment, and no relapse was complained even after withdraw of lateral ventricular drainage. During the treatment of lateral ventricular drainage, no complication of lateral ventricular drainage, such intracranial infection was observed, and combined the antifungal therapy, the early microbiological test results improved. Conclusion Lateral ventricular drainage is an effective, rapid and safe method to ameliorate headache in the early treatment of cryptococcal meningoencephalitis.%目的 观察侧脑室引流术在隐球菌性脑膜脑炎早期治疗中的临床效果,探讨其有效性与安全性.方法 对近年来我科治疗的5例初发隐球菌性脑膜脑炎伴高颅压患者的临床资料进行回顾性分析.结果 5例患者经早期行侧脑室引流后临床症状迅速缓解,撤除引流管后症状无加重；5例患者中无一例发生感染等并发症.联合抗真菌治疗后早期真菌学指标好转,长期随访中,4例患者临床治愈,无复发,1例死亡.结论 侧脑室引流是隐球菌性脑膜脑炎早期治疗中快速、安全缓解头痛症状及减少并发症的有效手段.