Objective To explore the effects of compound matrine oxygen inhalation on prevention of oral mucosal inflammation for patients after hemopoietic stem cells transplantation. Methods A total of 60 patients with allogeneic hemopoietic stem cells transplantation were divided into observation group (30 cases, routine oral nursing and compound matrine oxygen inhalation ) and control group ( 30 cases, routine oral nursing) by random number table. We observed the degree of oral mucosal inflammation and counted the position in two groups during pre-treatment period, low cell stage and convalescence stage from one day before pre-treatment period to 29 days after transplantation. Results The incidences of oral mucosal inflammation were 10. 0%, 56. 7%, 33. 3% in the observation group and 40. 0%, 100. 0%, 93. 3% in the control group during pretreatment period, low cell stage and convalescence stage (Z=3. 406, 5. 720, 5. 002;P<0. 05). There were significant differences in the numbers of occurrence sites between the two groups during pre-treatment period, low cell stage and convalescence stage (Z =2. 866, 6. 596, 5. 448;P <0. 05). Conclusions Compound matrine oxygen inhalation can decrease the degree of oral mucosal inflammation and reduce the occurrence sites of oral mucosal inflammation.%目的 观察雾化吸入复方苦参溶液防治异基因造血干细胞移植患者口腔黏膜炎的效果.方法 2013年6月-2014年12 月将60 例异基因造血干细胞移植患者按随机数字表法分为观察组30例、对照组30例;对照组采用常规口腔护理法,观察组在对照组的基础上加用复方苦参氧气雾化吸入. 从预处理前1 d起至移植后29 d,观察两组患者分别在预处理期、低细胞期、恢复期的口腔黏膜炎发生等级情况,并统计发生的部位. 结果 移植过程中观察组和对照组患者在预处理期、低细胞期、恢复期口腔黏膜炎的发生率分别为10. 0%,56. 7%,33. 3%和40. 0%,100. 0%,93. 3%. 预处理期、低细胞期和恢复期组间比较差异均有统计学意义(Z值分别为3. 406,5. 720,5. 002;P<0. 05);两组口腔黏膜炎发生部位个数比较,预处理期、低细胞期和恢复期组间比较差异均有统计学意义( Z 值分别为2. 866, 6. 596,5. 448;P<0. 05). 结论 复方苦参溶液雾化吸入可降低口腔黏膜炎的分级,减少口腔黏膜炎发生的部位.
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