丘脑底核电刺激术治疗原发性肌张力障碍

摘要

Objective To observe therapeutic effect of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) for primary dystonia. Methods Clinical data of 8 primary dystonia patients undergoing bilateral STN-DBS were analyzed retrospectively. The Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) and Unified Parkinson's Disease Rating Scale (UPDRS) were recorded preoperatively and 1, 3 and 6 months after the operation, and the improvement rates of the scores were calculated to evaluate the treatment outcomes. Results The mean improvement rates of BFMDRS and UPDRS scores were 47% and 48% 1 month after operation, 69% and 73% 3 months after operation, 75% and 79% 6 months after operation respectively. Conclusions STN-DBS can effectively improve the symptoms of patients with primary dystonia, and the therapeutic effect is stable. STN is an ideal target of DBS treatment for patients with primary dystonia.%目的 观察双侧丘脑底核(STN)脑深部电刺激(DBS)治疗原发性肌张力障碍的疗效.方法 回顾性分析8例接受双侧STN-DBS的原发性肌张力障碍病人的临床资料.分别在术前和术后1、3、6个月进行Burke-Fahn-Marsden肌张力障碍评分(BFMDRS)和帕金森病综合评分量表(UPDRS),计算两项评分改善率,评价治疗效果.结果 BFMDRS和UPDRS评分的改善率:术后1个月其均值分别为47％和48％,术后3个月为69％和73％,术后6个月为75％和79％.结论 STN-DBS可有效改善原发性肌张力障碍病人的症状,术后疗效稳定.STN是DBS治疗原发性肌张力障碍的理想靶点.