Objective: To study the surface potential decay of polypropylene (PP) electret through rat skin, and to investigate the influence of rat skin on external electric field of electrets and the mechanism of electret action on rat skin. Methods: The bare PP film and one-sided aluminum electrode coated PP film are prepared into positive and negative electrets by constant voltage corona charging, the surface charge decay of PP electrets through rat skin is studied by means of isothermal surface potential decay. Results: (1) To +1000 V electrets, after 48 hours, single electrode and bare electrets through rat skin kept 92.9% and 71.3% of the incipient potential, respectively. (2) To -1000 V electrets, 20.7% and 18.8% of the incipient potential decayed, respectively. (3) The PP electrets through rat skin showes good charge storage stability over 72 hours. Conclusions: (1) Both of single electrode and bare PP electrets exhibited good charge storage stability. (2) Single electrode PP electrets has higher surface potential through rat skin than bare PP electrets, and displayed better charge storage stability. (3) As a novel physical regulative factor and driving source, an electret could be used in transdermal patch study.%目的:研究聚丙烯驻极体透过大鼠皮肤的表面电位衰减情况,探讨大鼠皮肤对驻极体外静电场的影响及静电场对大鼠皮肤的作用机理,为研制优质的驻极体透皮给药贴剂奠定实验基础.方法:利用栅控恒压电晕充电系统将单电极和双裸面聚丙烯薄膜制备成正、负极性的驻极体,借助于等温表面电位衰减测量研究不同极性驻极体透过大鼠皮肤的等效表面电位衰减规律.结果:(1)+1000V注极的单电极和双裸面聚丙烯驻极体透过大鼠皮肤的表面电位经过48小时保留了其初始值的92.9％和71.3％.(2)-1000 V注极的单电极和双裸面聚丙烯驻极体透过大鼠皮肤的表面电位经过48小时后分别衰减了20.7％和18.8％.(3)聚丙烯驻极体透皮电位在72小时内具有和驻极体自身相近的稳定性.结论:(1)单电极和双裸面聚丙烯驻极体均具有优异的电荷储存稳定性.(2)驻极体的表面电位能很好的透过大鼠皮肤,相比双裸面驻极体,单电极驻极体透过大鼠皮肤的表面电位更高、稳定性更好.驻极体作为一种新的物理调控因子和驱动源可用于透皮给药贴剂的研制.
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