Intracranial hemorrhage (ICH) is associated with high mortality and disability rate.Nowadays,only CT and MRI can be used for the detection of bleeding but they fail to monitor the change ofICH timely and can't be applied for pre-hospital care.Magnetic inductive phase shift (MIPS) using alternating magnetic field to measure the conductivity is a non-invasive and non-contact method,which has been applied in the commercial measurement and food detection.Herein,a double-end exciting coil was developed to detect the MIPS after ICH in rabbit brain for evaluating the changes of bleed volume,and the MIPS parameters were phase difference.In blood injection group,ICH was simulated by injecting 3 mL of autologous blood into the rabbit brain at a constant speed of 3 mL/h,and MIPS parameters were measured synchronously.The MIPS parameters measured before 1 h of blood injection were taken as the controls.Moreover,MRI scan group was established by performing the same blood injection procedure and scanning rabbit brain with MRI synchronously.The results showed that the MIPS value initially declined and then increased with the increasing blood injection volume,showing a turning point.Statistical differences were found between blood injection group and controls group (P＜0.05).The MRI scanned images indicated that the average reduced volume of cerebrospinal fluid (CSF) in the rabbit brain after blood injection was approximately equal to the average injection volume that corresponds to the turning point of the MIPS.Thus,we conclude that CSF is already exhausted and the compensatory stage has already ended when the MIPS turning point occurs.MIPS method has the potential to detect the CSF compensation end after ICH in a non-contact and non-invasive manner,warning the intracranial hypertension caused by ICH.%脑出血属于脑卒中的一种,具有极高的死亡率和致残率.当前只能通过CT和MRI来检测出血,但是这些影像学设备并不能实时监护脑出血的发展变化,其次,也不能用于院前急救.磁感应相位移方法(MIPS)是一种利用交变磁场,无创、非接触测量被测物电导率的方法,在工业测量、食品检测方面已有研究应用.本文尝试利用该方法测量家兔脑出血的发展变化.文中设计了一个双端激励线圈用于家兔脑出血的MIPS测量,测量参数为相位差.实验首先建立家兔的自体血注射致脑出血过程,3mL自体血1h内匀速注射进兔脑内囊中,在注射过程中同步测量MIPS参数.注血组未注血之前1h的MIPS测量数据为对照组.此外还建立了MRI扫描对照组,该对照组注血过程与实验组完全一致,但注血过程中不进行MIPS测量,而同步使用MRI扫描兔脑.实验结果表明,随着注血量的增加,实验组MIPS数据呈现出先下降后上升的趋势,存在一个转折点.实验组与对照组存在显著的统计学差异(P＜0.05).而MRI扫描组统计表明注血过程中兔脑脑脊液减少量近似等于实验组MIPS拐点出血对应的注血量.脑出血过程MIPS的拐点出现时刻近似对应脑脊液代偿结束时刻,因此MIPS方法有可能对脑出血致颅内压升高进行预警,具有重要的临床应用价值.
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