癫痫伴发焦虑抑郁患者脑神经递质活动的脑电超慢涨落图表现分析

摘要

Objective To explore and analyze the encephalofluctuograph(EFG)features of intracerebral neurotransmitter activity in epileptic patients with anxiety and depression.Methods Thirty epileptic patients with anxiety and depression treated in Guangxi Zhuang Autonomous Region Brain Hospital from January 2014 to December 2015 were regarded as observation group,while 30 epileptic patients without anxiety and depression treated in the same hospital over the same period were regarded as control group.The EFG analyzer was used to detect the changes in intracerebral neurotransmitter activity and brain functional states in the two groups. Results No significant differences were found in intracerebral neurotransmitters between the two groups (P>0.05),except 5-HT which was significantly lower in observation group compared to control group.The exercise index, excitability and depression index,and vasomotor index in observation group were higher than those in control group,with significant differences(P<0.05).Conclusion The EFG characteristics in epileptic patients with anxiety and depression include abnormal intracerebral neurotransmitter activity and abnormal brain functional states,and these abnormalities are helpful in the differential diagnosis of epilepsy with anxiety and depression.%目的:探讨癫痫伴焦虑抑郁患者脑神经递质活动的脑电超慢涨落图(EFG)表现并对其进行分析.方法:以2014年1月~2015年12月我院治疗的30例癫痫伴焦虑抑郁患者(记为观察组)、同期于我院治疗的30例癫痫患者(无焦虑抑郁者记对照组)为对象,采用EFG分析仪检测两组研究对象脑内神经递质活动变化情况、脑功能状态差异.结果:观察组仅5-HT较对照组明显低,其它指标两组之间比较无明显差异(P>0.05);两组运动指数、兴奋抑郁指数及血管舒缩指数由高至低排序为:观察组>对照组,两组之间比较差异显著(P<0.05).结论:癫痫伴焦虑抑郁患者的EFG表现为脑神经递质的活动异常、脑功能状态处于异常状态,而这些异常表现有助于癫痫伴焦虑抑郁的鉴别诊断.