脂溢性秃发的病因探讨

摘要

目的探讨脂溢性秃发（脂秃）的病因。方法通过患者秃发区皮肤组织免疫组化定位染色法，进行性激素受体检测，同时测定血清中微量元素Fe、Cu、Zn及超氧化物歧化酶（SOD）、丙二醛（MDA），以及对问诊调查进行比较分析。结果脂秃患者秃发区雄激素受体（AR）表达明显高于正常人，但与家族史无关，约35 %脂秃患者秃发区头皮组织无AR阳性表达。脂秃患者血清中Fe元素及SOD的含量比正常人明显减少。100 %脂秃患者与两个以上相关因素有关。结论脂秃是一种多因素的疾病。%Objective　 To investigate aetiology of alopecia seborrhoeica. Methods　Immunocytochemical localization of androqenic receptor(AR) was performed in the skin with baldness, and serum Fe,Cu,Zn,SOD and MDA detected, together with an interrogation. Results　 Expression of androgenic receptor in alopecia was higher than that in normal controls.There was no correlation between the positive expression of AR and familial history. No expression of AR was found in about 35 % of the patrents.More than two factors involved in the pathogenesis of alopecia seborrhoeia.. Conclusion 　Alopecia seborrhoeica is a disease entity related to multple pathogenic factors.