不均匀场下空间编码超快速高分辨NMR研究进展

摘要

The proposal and development of two-dimensional nuclear magnetic resonance (2D NMR) provide a broad space for the research and application of NMR.In many cases,however,high-resolution 2D spectra are virtually impossible to obtain because of the inherent heterogeneity of the samples under investigation,as well as the poor homogeneity of the magnetic fields.It is also time-consuming to obtain a conventional 2D NMR spectrum.The ultrafast spatial encoding technique enables acquisition of a 2D or multi-dimensional NMR spectrum within a single-scan,with greatly shortened acquisition time.Schemes based on phase compensation,coherence transfer and intermolecular multiple quantum coherence in combination with spatial encoding technique have been proposed to ultrafast obtain high-resolution NMR spectra in inhomogeneous fields.In this review,ultrafast high-resolution NMR techniques were introduced and the perspective of these techniques was discussed.%二维核磁共振(2D NMR)的提出和发展,为NMR技术的研究和应用提供了广阔的空间.然而当样品或磁场本身不均匀时,高分辨的2D NMR谱难以获得.此外,常规2D NMR实验通常需要长的采样时间.空间编码超快速采样方法利用空间编码技术,只需单次扫描即可获得2D甚至多维NMR谱,极大地缩短了采样时间.目前相位补偿、相干转移和分子间多量子相干等技术与空间编码技术相结合,已成功实现不均匀场下超快速获得高分辨NMR谱.该文对不均匀场下空间编码超快速NMR方法进行了介绍,对其未来发展进行了展望.