洛莫司汀的1H、13C NMR全归属

摘要

应用1H NMR、13C NMR、DEPT135、1H-13C HMBC、1H-13C HSQC、1H-1H COSY和1H-1H NOESY等多种NMR技术，对文献报道的洛莫司汀（Lomustine）1H和13C NMR数据进行了修正与补充；特别是应用2D NMR对重叠程度较高的环己烷区进行了指认归属，并确定了其空间构型。%Lomustine is an important drug having chiral carbon atoms. In the present study, one-dimensional1H and13C NMR, as well as two-dimensional techniques (i.e.,1H-13C HMBC,1H-13C HSQC, 1H-1H COSY and1H-1H NOESY) were used to elucidate the structure of Lomustine. The proton and carbon chemical shifts of the compound were assigned.