磁敏感加权成像在帕金森病脑核团铁含量的定量研究

摘要

目的：利用磁敏感加权成像测量和分析PD脑深部核团铁含量特点。材料与方法研究对象为40例PD患者和36例正常志愿者，利用3.0 T磁共振扫描仪获取研究对象SWI图像，通过SPIN软件在获取的SWI相位图中测量脑深部灰质核团苍白球、壳核、黑质相位值，并将获取的研究对象核团相位值进行配对样本t检验，P＜0.05为差异具有统计学意义。结果 PD组黑质相位值平均值最小(R，2034.84；L，2030.55)。PD组与对照组相比，右侧苍白球(P=0.018)、黑质相位值(P=0.008)和左侧苍白球(P=0.040)、黑质相位值(P=0.000)均具有显著性差异。PD组右侧苍白球与右侧黑质(P=0.000)、右侧壳核与右侧黑质(P=0.000)、左侧壳核与左侧黑质(P=0.000)相位值对比差异具有统计学意义。结论 PD病患者黑质铁含量最多，苍白球和黑质铁含量成对称性增多。磁敏感加权成像可为PD病诊断提供参考信息。%Objective:Aiming to measure and analyse the iron content in cerebral nucleus of the Parkinson's disease (PD) subjects.Materials and Methods:Forty PD subjects and 36 volunteers were recruited in the cross-sectional study. Susceptibility weighted images (SWI) was acquired for all participants. Phase values of globus pallidum (GP), putamen (PUT), substantia nigra (SN) were measured by SPIN software. Paired-samplet test was used to compare the phase values of nucleus, P<0.05 was considered to be statistically signiifcant.Results:Phase values in SN of PD subjects were least (right, 2034.84. left, 2030.55). Phase values of bilateral GP (R, P=0.018. L,P=0.040) and bilateral SN (R,P=0.008. L,P=0.000) showed signiifcantly statistical differences between PD subjects and volunteers. There were significantly statistical differences in phase values between right GP and SN (P=0.000), right PUT and SN (P=0.000), left PUT and SN (P=0.000) in PD subjects.Conclusions:SN showed highest iron content in patients with PD, iron content increased symmetrically in GP and SN of patients with PD. SWI provided information for the diagnosis of PD.