低频强声对大鼠肝脏和脾脏形态学影响

摘要

Objective To evaluate the effects of strong low-frequency sound on liver and spleen of rats. Methods The rats were randomly exposed to a closed sound field and acousticly stimulated by strong low-frequency sound of 103 Hz or 300 Hz, respectively. The exposure time was 5 min and 10 min, respectively. On the basis of observation time, each group were divided into immediate group, 3 days group and 7 days group. The liver and spleen histopathology were observed based on the injury severity criteria. Results Different degrees of vascular dilation, congestion, edema were found in liver and spleen of the exposed rats when observed under light microscope. Conclusions Strong low-frequency sound can cause liver and spleen injury.%　　目的探讨低频强声对肝脏及脾脏组织形态学的影响。方法随机将大鼠暴露于频率为103 Hz或300 Hz的声场中，暴露时间分别为5分钟和10分钟。根据暴露的频率和作用时间，分为4个实验组和对照组。依据暴露后观察时间，每组再分为即刻组、3天组和7天组。依据肝脏、脾脏损伤程度判断标准，对低频强声暴露后及对照组肝脏、脾脏组织病理学进行观察。结果与对照组比较，各实验组光镜下肝脏、脾脏均有不同程度的血管扩张、充血、淤血及组织水肿等改变。结论低频强声可导致肝脏、脾脏损伤。