Sotatol is a nonselective β sympathetic antagonist with additional class Ⅲantiarrhythmic drug activity.In this study,we reported intravenous sotalol inthe suppression of inducible sustained ventricular techycardia guided byelectrophysiologic study and its alectrophysiologic effects.Patients withdocumented sustained ventricular tachycardia or had been resuscitated fromhaemodynamically unstable VT or VF were considered eligible forelectrophysiologic study.Only 21 patients who had sustained ventriculartachycardia induced by programmed ventricular stimulation receivedintravenous sotalol 1.5mg/kg within 15-20 mins after termination oftachycardia.16 patients has coronary artery disease and 5 had dilatedcardiomyopathy.The mean induced VT cycle length was 276±54ms.Repeatprogrammed ventricular stimulation was then performed.Of 21 patients,9(43%)had their sustained ventricular arrhythmia non-inducible and 11 hadtheir VT still inducible.Among the 11 patients who were inducible VT,5was difficult for induction and mean VT cycle length was prolongedsignificantly by sotalol compared with baseline.Sotalol prolonged markedlyright ventricular effective refractory periods(RVERP),sinus cycle length,QT interval,atrial ventricular nodal and intraventricular conduction time.There were no significant differences of the electrophysiologic parametersbetween the group of patients in whom the arrhythmia were suppressed andthe group of patients in whom the arrhythmias were not suppressed.Conclusion Sotalol is an effective drug for the suppression of ventriculartachycardia as judged by programmed electrical stimulation.It prolongedsignificantly RVERP and inhibited cardiac conductive system.
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