The Relatlonahlp Between Pleame Calcltonin Gane-Rslated Peptlds Leval and Early Cardlac Dyafunetion In Patianta with Coronary Artery Dlsease

摘要

To identify whether plasma Calcitonin gene-related peptide （CGRP） level isindexe for evaluating early cardiac dysfunction in patients with coronaryartery disease.Normal and coronary artery disease total sixty cases werechosen at random,which were diagnosed by coronary arteriography,foursubgroups （0,1,2,3 lesion branch group） were divided basing on coronaryartery lesion branch,each having fifteen cases.hemodynamic parameters weremeasured by left cardiac cather and left ventricular cineangiography,plasmaCGRP concentration was msaured by radioimmunoassay.results reveal:LVEFdecressed as coronary artery lesion branch increased,but there were nosignificantly difference between subgroups (only Psio0.05);there weresignificantly difference of diastolic function parameters between subgroups,especially T,bad positive relativity to stenosis score （r=0.72,P0.01）.Plasma CGRP level had positive relativity to stenosis score,time constant（r=0.37～0.38,P0.05）;bad negative relativity to LVEF （r=-0,46,P0.01）.in brief,Coronary artery disease imparies diastolic function prior tosystolic function;CGRP is a important index for evaluating early cardiacdysfunction in patients with coronary artery disease.