EFFECT OF THE GENE POLYMORPHISM OF LOW DENSITY LIPOPROTEIN RECEPTOR ON THE EFFICACIES OF THE LIPIDS REGULATION OF MICRONIZED FENOBRITE

摘要

Objective:To observe effect of the gene polymorphism of low density tipoproteinreceptor on the efficacies of the lipids regulation of micronized fenobrite.Methods:Fifty two patients with hyperlipidemin(serum total cholesterol level exceeded or equalto 5.20mmol/L,and/or triglycoride level was in the range 2.00-5.65 mmol/L)wererandomly allocated into Fenobrite group and placebo group (30 and 22 cases,respectively).The low density lipuprotein receptor HineⅡ polymorphism weremeasured by polymerase chain reaction technology.Results:Comparing theefficacaes of regulation of lipids of Fenobrite and placebo among the subgroups withH1H1,H1H2,or H2H2 genotype of low density lipoprotein receptor HincⅡpolymorphism,we did not find that the efficacy rates(10 % fall in total cholesterol andin low density lipoprotein cholesterol,20% fell in triglyceride,and increase more than0.1 mmol/L in high density lipoprotein cholesterol respectively)of patients witlH1H1,H1H2 or H2H2 genotypes were significantly different amaong the differengenotytes of Fenobrite and control groups.The lowered ranges of total cholesterollow density lipoprotein cholesterol,and triglyceride were neither marked differenamong the patients with H1H1,H1H2,and H2H2 genotypes,average reductionpercent of total cholesterol were in sequence 30.3,30.2,and 33.4%(P0.05),lowdensity lipoprotein cholesterol were 28.0,29.1,and 31.8%(p0.05),triglyceridwere 55.2,53.9,and 53.2%(P0.05)Responsiveness were less different betweenpetients with h1 allele and h2 allele in Fenobrite and placebo group.ConcluslonThe result of present study suggested that low dansity lipoprotein receptor Hinealleles do not took part in the key processes of the cholesterol or triglyceride regulationof Fenobrite.