OBSERVATION OF QUINIDINE ON THE CARDIOVERSION TREATMENT IN PATIENTS WITH RHEUMATIC MITRAL STENOSIS AND ATRIAL FIBRILLATION AFTER PERCUTANEOUS BALLON MITRAL VALVULOPLASTY

摘要

Background:Pharmacologic therapy has been advocated for bothcardioversion and prevention of recurrent atrial fibrillation.Quinidine is thetherapeutic mainstay for both purpose.Method:Twelve patients withrheumatic mitral stenosis and persistent atrial fibrillation recieved quinidineafter percutaneoas ballon mitral valvuloplasty within 3-6 weeks.If heart rate100bpm,it was decreased with intravenous or oral digoxin,wbereafter 200mgof oral quinidine was given maximally 5 times,each dose 2 hours apart.Afterconversion of atrial fibrillation to sinus rhythm.All patients recieved 200mg oforal quinidine once or twice a day for prevention of recurrence.Result:Allpatients were converted to sinus rhythm and two of patients had recurrence ofatrial fibrllation within three months after cardioversion treatment.The sideeffect included diarrhea,vomit and bleeding tendency.Conclusion:Quinidineis effective in conversion of atrial fibrillation to sinus rhythm and is associatedwith an acceptable efficacy rate in preventing recurrence of atrial fibrillation.It shows that proper supply of drug,careful observation of side effects andpatient psychological nursing is also important to quinidine cardioversiontreatment.