舒肝养血安神法治疗焦虑症的临床研究

摘要

Objective To evaluate the efficacy,safety and feasibility of soothing liver,nourishing blood and tranquilizing mind therapy (SLNBTMT)in the treatment of anxiety disorders.Methods One hundred and fifty nine patients were eventual y included in the study,and randomly divided into two groups:control group(n=78)treated with flupentixol and melitracen tablets,and treatment group(n=81)treated with SLNBTMT for 42 days.The clinical effect assessments were taken before treatment,7 days,14 days,28 days,42 days and one month after treatment.The disease severity was assessed by the Hamilton anxiety rating table (HAMA),Zung Self Rating Anxiety Scale(SAS),Symptom Checklist 90 (SCL 90).Safety was assessed by using laboratory examination and the Treatment Emergent Symptom Scale (TESS).Results There was no statistical y significance in the scores of HAMA,SAS,SCL 90 between treatment group and control group before treatment.After treatments,the efficacy of treatment group was significantly better than that of control group(P<0.05).Conclusion SLNBTMT has better long term efficacy and lighter adverse reaction,which is better than flupentixol and melitracen tablets.%目的：整理养血舒肝安神法治疗广泛焦虑症病人的初诊处方,评价舒肝养血安神法治疗焦虑症的疗效、安全性和可行性。方法采用随机、双盲、平行对照研究,159例病人最终纳入研究,随机分为治疗组和对照组,治疗组81例,对照组78例。治疗组给予舒肝养血安神法治疗,对照组给予氟哌噻吨美利曲辛片1片每日2次,疗程为42 d。在治疗前和治疗后7 d,14 d,28 d,42 d及治疗结束一个月后进行临床疗效,应用汉密尔顿焦虑量表(HAMA),Zung氏焦虑自评量表及症状自评量表对病情严重度评定。用副反应量表(TESS)检查评定安全性。结果与治疗前比较,治疗后治疗组与对照组中医临床疗效,汉密尔顿焦虑量表评分, Zung氏焦虑自评量表评分、症状自评量表评分比较差别无统计学意义；治疗后,治疗组疗效明显高于对照组,两组差别有统计学意义(P<0.05)。结论舒肝养血安神法治疗广泛性焦虑障碍病人疗效确切,起效快,不良反应轻。