类风湿关节炎病人致动脉粥样硬化指数及黏附分子水平的变化

摘要

Objective To study the relationship between serum atherogenic index of plasma (AIP)and adhesion molecular(AM)by AIP and AM levels in patients with rheumatoid arthritis(RA).Methods Sixty patients with RA were selected.The levels of serum AIP, soluble vascular adhesion molecular 1(sVCAM 1),soluble inter cel ular adhesion molecules 1(sICAM 1),E selectin were determinated.The erythrocyte sedimentation rate (ESR),C reactive protein (CRP)and other indicators were compared.The corre-lation among the indicators was analyzed.Results Compared with normal control group,the serum AIP level was significantly in-creased in patients with RA(0.83± 0.31 vs 0.21± 0.18,P<0.01).The levels of serum sVCAM 1,sICAM 1,E selectin in patients with RA were significantly higher than that in normal control group(P<0.01).The serum sVCAM 1,sICAM 1 and AIP were posi-tively correlated in patients with RA(r= 0.727,P<0.01;r= 0.501,P<0.01).Conclusion The levels of serum AIP and AM are sig-nificantly increased in patients with RA.Serum Svcam,sICAM 1 and AIP are positively correlated.It is suggested that sVCAM 1 and sICAM 1 may play a role in the occurrence of atherosclerosis in patients with RA.%目的：通过比较类风湿关节炎病人致动脉粥样硬化指数(AIP)和黏附分子(AM)的水平,研究 RA病人中血清 AIP和黏附分子的关系。方法测定60例RA病人中血清AIP和可溶性细胞间黏附分子1(sICAM 1)、可溶性血管细胞间黏附分子1(sVCAM 1)、E 选择素(E selectin)的水平,并分别比较血沉、C反应蛋白(CRP)、指标,分析各指标间的相关性。结果与正常对照组比较,RA病人 AIP水平有明显升高(0.83±0.31比0.21±0.18,P<0.01)。RA病人血清 sVCAM 1、sICAM 1、E 选择素与正常对照组比较有明显升高(P<0.01。RA病人血清中的 sVCAM 1、s ICAM与 AIP呈正相关(r=0.727,P<0.01；r=0.501,P<0.01),而 E选择素与 AIP之间无相关性。结论 RA病人致动脉粥样硬化指数和血清黏附分子水平明显增高,且 s VCAM、s ICAM与 AIP呈正相关。提示 sVCAM 1、sICAM 1可能与 RA病人动脉粥样硬化的发生起着一定的作用。