中药抗耐甲氧西林金黄色葡萄球菌生物膜研究进展

摘要

金黄色葡萄球菌是临床感染最为常见的病原菌，抗生素滥用使细菌耐药性增强，耐甲氧西林金黄色葡萄球菌（MRSA）是主要突变株。生物膜的产生进一步降低了抗生素对 MRSA 菌体的杀伤作用，使该疗法受到更多限制。新的抗 MRSA 感染药物亟待开发，中药作为天然药物受到更多关注，本文就近年来中药抗MRSA生物膜的研究进行综述，为新药研发提供参考。%Staphylococcus aureus is one of the most common clinical infectious pathogens, and abused antibiotics enhances its resistance. Methicillin-resistant Staphylococcus aureus (MRSA) is the major mutant strains. The generation of biofilm reduces the effects of antibiotics on Staphylococcus aureus, which makes the antibiotic therapy limited. New medicine need to be developed, and TCM as the natural medicine is becoming a hot spot. This article reviewed the research of TCM against MRSA biofilmsin recent years, and provided references for research and development of new medicine.