维生素D联合维生素C、乳酸杆菌制剂治疗妊娠期细菌性阴道病随机对照研究

摘要

Objectives:To investigate the clinical effect of oral vitamin D combined with vitamin C and lac-tobacillus vaginal medication in the treatment of gestational bacterial vaginal disease.Methods:1 30 patients with gestational bacterial vaginal disease in hospital from October 201 0 to October 201 2were selected and randomly divid-ed into two groups.65 patients treated oral vitamin C and lactobacillus vaginal medication as control group.65 pa-tients treated with oral vitamin D combined with vitamin C and lactobacillus vaginal medication as observation group. After a week of treatment,patients were followed up for a month.Patients reexamined a week and a month after drug withdraw.The therapeutic effect,recurrence and pregnancy outcome were compared.Results:The total efficiency in observation group was significantly higher than control group.In the reexamination,the vaginal pH,leucorrhea abnormal rate,positive rate of BV detection in observation group were significantly lower than those in control group,while serum vitamin D and symptom improvement rate in observation group were significantly higher than control group.Incidence of membranes premature rupture,puerperal infection,premature birth,low birth weight rate and neonatal infection in observation group were significantly lower than control group.All the differences were statistically significant (P <0.05).Conclusions:Curative effect of oral vitamin D combined with vitamin C and lactobacillus vaginal medication in the treatment of gestational bacterial vaginal disease is significant,with low ad-verse pregnancy rate and high safety.Oral vitamin D combined with vitamin C and lactobacillus vaginal medication can significantly improve prognosis of patients and fetus,which is worthy clinical application.%目的：探讨口服维生素 D 联合维生素 C、乳酸杆菌制剂阴道用药治疗妊娠期细菌性阴道病的临床疗效。方法：选取本院2010年10月至2012年10月诊治的妊娠期细菌性阴道病患者130例，采用数字随机法分为两组，65例患者口服维生素 C、乳酸杆菌制剂阴道用药治疗为对照组，65例患者口服维生素 D联合维生素 C、乳酸杆菌制剂阴道用药治疗为观察组，治疗1周后随访1月，停药1周、1月时行复查。比较两组患者的治疗效果、复发情况、妊娠结局。结果：观察组患者总有效率明显高于对照组。停药1周、1月时复查，观察组患者阴道 pH 值、白带异常率、BV 检测阳性率均明显低于对照组，观察组患者血清维生素 D、症状改善率均明显高于对照组。观察组患者胎膜早破发生率、产褥感染发生率、早产发生率、新生儿低体重发生率、新生儿感染发生率均明显低于对照组，差异均有统计学意义（P ＜0.05）。结论：口服维生素 D 联合维生素 C、乳酸杆菌制剂阴道用药治疗妊娠期细菌性阴道病的疗效显著，不良妊娠率低且安全性高，可明显改善患者及胎儿的预后，值得临床推广使用。