西地那非联合苁蓉益肾颗粒治疗2型糖尿病性勃起功能障碍的疗效及安全性分析

摘要

Objectives:To observe the efficacy and safety of sildenafil combined with congrongyishen granules for the treatment of patients with erectile dysfunction (ED) and type 2 diabetes mellitus.Methods:A total of 70 ED patients with type 2 diabetes mellitus were randomly divided into 2 groups.Group A (35 patients) was given sildenafil treatment alone for 4 weeks and Group B (35 patients) was treated with sildenafil combined with congrongyishen granules for 4 weeks.Before and after the treatment,the mean international index of erectile function-5 (IIEF-5),sexual intercourse frequency each week,intercourse satisfaction and the drug adverse effect of patients were evaluated.Results:After treatment,both groups had significant increases in IIEF-5,sexual intercourse frequency each week and intercourse satisfaction (P ＜ 0.05).The increase of IIEF-5 and intercourse satisfaction in Group B was more significant than that in Group A (P ＜ 0.05).No adverse events were noted in the two groups.Conclusion:Compared to sildenafil therapy only,sildenafil combined with congrongyishen granules can improve the sexual function of ED patients with type 2 diabetes mellitus,leading to a satisfactory sexual life.%目的:探讨西地那非联合苁蓉益肾颗粒治疗2型糖尿病性勃起功能障碍(erectile dysfunction,ED)的疗效及安全性分析.方法:将70例二甲双胍药物控制的2型糖尿病性ED患者随机分为A、B两组,A组35例,服用西地那非;B组35例,联合服用西地那非和苁蓉益肾颗粒,两组均治疗4周.分别对治疗前后国际勃起功能指数-5评分(international index of erectile function,IIEF-5)、每周性交频率、夫妻双方性生活满意程度进行统计分析,并观察两组患者治疗期间的不良反应.结果:A、B两组在IIEF-5评分、每周性交频率、夫妻双方性生活满意程度方面均较治疗前增加,差异具有统计学意义(P＜0.05),但B组治疗后在IIEF-5评分、夫妻双方性生活满意程度高于A组治疗后,差异具有统计学意义(P＜0.05).两组患者治疗期间未发生严重不良反应.结论:西地那非联合苁蓉益肾颗粒治疗2型糖尿病性ED较单用西地那非可显著改善患者的勃起功能,提高夫妻性生活质量,安全、有效.