急性淋巴细胞白血病患者血清IL-3、IL-6、IL-8水平的测定及其临床意义

摘要

目的探讨IL-3、IL-6、IL-8在急性淋巴细胞白血病(AIL)中的意义。方法采用酶联免疫法(ELISA)测定45例急性淋巴细胞白血病患者血清IL-3、IL-6、IL-8水平。结果 AIL初诊患者血清IL-3水平明显低于正常对照组(P＜0.05)，血清IL-6、IL-8水平明显高于正常对照组(P＜0.05、P＜0.001)，经治疗AIL CR期患者IL-3、IL-6、IL-8水平恢复正常；AIL NR组与初诊组相比无显著性差异(P＞0.05)。结论检测IL-3、IL-6、IL-8水平的变化有助于判断AIL患者病情的变化，并可作为监测治疗反应的辅助指标。%Objective To investigate the prognostic significance of interleukin(IL) - 3,6, 8 levels in patients with acute lymphocytic leukemia(AIL). Method ELISA assay were employed to investigate the levels of IL - 3, IL - 6 and IL - 8 in 45 AIL patients. Results The levels of IL - 3 were much lower at the time of diagnosis when compared with controls(P ＜ 0.05), otherwise the levels of IL- 6 and IL- 8 were higher in comparison with controls(P ＜ 0.05,P ＜ 0.001 respectively).The levels returned to normal levels in those who got completely remission(CR). There was no difference between the patients who failed to get CR and denovo patients. Conclusion Dunamic monitoring the levels of IL - 3, IL - 6 and IL - 8 may have prognostic value in clinical outcome and is useful marker treatment of AIL patients.