急性心肌梗死患者血清TC/HDL-C水平与冠脉病变程度关系研究

摘要

目的探讨急性心肌梗死（AMI）患者血清总胆固醇/高密度脂蛋白胆固醇比值（TC/HDL-C）与冠脉病变程度的关系。方法随机选取2010年～2012年急性心肌梗死患者行经皮冠状动脉介入治疗者60例，并根据TC/HDL-C水平按四分位法随机分为4组。观察4组患者冠脉造影结果，分析TC/HDL-C与冠状动脉评分之间的关系。结果随着TC/HDL-C水平的升高，患者3支血管病变的比例增大，各组间差异有统计学意义（P均＜0.05）。血浆TC/HDL-C水平与冠脉病变Gensini积分呈正相关（r=0.775，P＜0.05）。结论急性心肌梗死患者TC/HDL-C水平越高，其冠脉病变程度越重，心血管事件发生率越高。TC/HDL-C可以作为判断急性心肌梗死病情和冠脉病变程度的一个指标。%Objective To study the relationship between total cholesterol/high-density lipoprotein cholesterol ratio and the degree of coronary stenosis in the patients of acute myocardial infarction.Methods A total of 60 patients with documented CHD were enrolled in this study for measurement of serum concentrations of TC and HDL-C.Accrding to the level of TC/HDL-C ratio,we separate the patients into 4 groups,and compare the results of their CAG.Results The concentration of TC/HDL-C ratio has powerful association with the degree of vascular stenosis.The higher of TC/HDL-C ratio,the more severe of the degree of coronary stenosis.Conclusion Detection of TC/HDL-C may facilitate early diagnosis of CHD.