神经生长液改善老年帕金森病患者非运动症状的疗效

摘要

目的：探讨神经生长液对帕金森病（ PD）患者非运动症状（ NMS）临床治疗效果。方法采用 PD 非运动症状30问卷筛查量表（ NMSQuest）对48例PD患者的NMS进行评估，并选用Hoehn-Yahr（HY）分期、PD统一评分量表-3（UPDRS-3）、多巴丝肼用量作为评估患者运动功能的指标，同时结合年龄、性别、发病时间、受教育程度等可能影响患者NMS的因素评估对PD患者NMS影响的程度。结果 PD非运动症状30问卷筛查量表（ NMSQuest）显示PD患者NMS极其普遍。 NMS评分与病程、UPDRS3、HY分期呈正相关。患者治疗后多巴丝肼用量、UPDRS3评分与治疗前的差异无统计学意义（P＜0.05），NMSQuest得分比治疗前显著降低（P＜0.05）。特别是生动梦境、不明原因的疼痛、注意力下降、失眠、便秘、头晕等症状改善明显。结论神经生长液可明显改善PD患者的NMS从而提高生活质量。%Objective To investigate the curative effect of nerve growth decoction ( NGD) for treatment on non-motor symptoms ( NMS) of Parkinson's disease ( PD).Methods The NMS in 48 patients with PD were estimated using the PD NMS Questionnaire.Mean-while Hoehn-Yahr(HY) scale, unified PD rating scale(UPDRS) part3, Levodopa and Benserazide tablet dosage were used to assess motor symptoms.The factors, affected the NMS in the patients, such as age, sex, time of onset, educational level and as on were also investiga-ted.NGD had been administered by 1 package/day, 1 therapy duration/30 days, and next therapy duration continued after the therapy inter-val of 1~2 weeks.The whole therapy period was 2 to 3 durations and intervals cycled as aboved.Evaluations were observed before and after treatment.Results NMSQuest showed that NMS in PD were common and frequent.There was a significant association of total NMS score with duration, UPDRS3 score and HY stage.The differences of Levodopa and Benserazide tablet dosage and UPDRS 3 score before and after treatment had not statistical significance .NMSQuest scores were significantly reduced after treatment compared to those before treatment (P<0.05).Especially the symptoms of vivid dreams , unexplained pain, attention, insomnia, constipation, dizziness and other symptoms im-proved significantly.Conclusions NGD has positive effects on NMS in PD patients and improve quality of life.