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老年2型糖尿病合并急性脑梗死的相关危险因素

     

摘要

目的:对2型糖尿病合并急性脑梗死(DCI)老年患者的各项指标进行探讨分析。方法根据有无乙型糖尿病(T2DM)分为DCI组117例和无T2DM的急性脑梗死(ACI)患者137例为对照组,对两组的临床资料进行回顾性分析。结果 DCI组血糖、糖化血红蛋白、血尿酸、尿微量白蛋白、纤维蛋白原、三酰甘油、总胆固醇、低密度脂蛋白胆固醇、载脂蛋白B、脂蛋白(α)、血肌酐及γ-谷氨酸转肽酶的水平均较对照组明显升高;高密度脂蛋白胆固醇、载脂蛋白A1水平则显著低于对照组。结论对T2DM老年患者早期严格控制血糖,调整脂代谢紊乱,控制尿微量蛋白、高纤维蛋白原、高尿酸等危险因素,是减少脑梗死发生的重要手段。%Objective To explore and analyze various kinds of lab indication in patients with type 2 diabetes mellitus(DM) compli-cated with acute cerebral infarction ( ACI) ( DCI) .Methods Retrospective investigation and analysis were carried out in 117 DCI patients and 137 cases of ACI patients without type 2 DM as the control group .Results the concentrations of fasting blood sugar ,Hemoglobin A1c, blood uric acid ,plasma fibrinogen ,urinary microalbumin ,triacylglycerol ,total cholesterol ,low density lipoprotein cholesterol ,apolipoprotein B , lipoprotein(α),serum creatinine and γ-glutamate transpeptidase levels in DCI group were significantly higher than those in control group (all P<0.05),but the concentration of high density lipoprotein cholesterol and apolipoprotein A 1 in DCI group were markedly lower than those in control group(P<0.05).Conclusions Early vigorous intervention of risk factors including blood glucose ,hyperuricemia,dyslipidemia,hy-perfibrinogenemia ,and urinary microalbuminuria may be the key to reduce complicating ACI in patients with type 2 DM.

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