心理语言、穴位刺激和胃电起搏协同改善功能性消化不良的胃感觉功能

摘要

目的 研究心理语言、穴位刺激、胃电起搏协同治疗方法(Coordinated Treatment of Psychological language,Acupuncture point stimulation and Gastric pacing,CTPAG)治疗难治性功能性消化不良的临床疗效及可能机制.方法 根据罗马Ⅲ标准选取80例难治性功能性消化不良患者,随机分为两组:口服药物组(n=38)和CTPAG组(n=42),比较两组受试者在症状评分、临床疗效、胃感觉功能中的差异.结果 与口服药物组比较,CTPAG组中临床症状评分明显下降,疗效显著率明显升高；胃的初次饱足阈值和最大耐受阈值均明显增加,差异具有统计学意义(P＜0.05).结论 心理语言、穴位刺激和胃电起搏协同治疗(CTPAG)可能通过增加胃的可耐受容积,降低内脏敏感性,达到改善早饱、腹胀、进食少等疗效；并且CTPAG组优于常规口服药物组,是难治性FD非药物治疗的一种新选择.%Objective To investigate a new method for treating intractable functional dyspepsia (FD) with Coordinated Treatment of Psychological language, Acupuncture point stimulation and Gastric pacing ( CTPAG). Methods Eighty intractable FD patients were selected according to the Rome III criteria. Two groups were separated randomly o o-ral application group ( n = 38 ) and CTPAG group ( n = 42). The scores of clinical symptom, therapeutic effect and gastric sensory function were all evaluated and analyzed. Results In the CTPAG group, the scores of clinical symptom were descended, the ratios of therapeutic effect were elevated, and the satiation threshold values were also elevated compared with the oral application group (P < 0.05). Conclusion CTPAG, a new choice for treating intractable functional dyspepsia is effective and reliable. The curative effect surpasses the traditionary method of oral application. CTPAG may increase gastric tolerant volume, decrease visceral sensitivity and achieve to improve the symptoms such as early full, abdominal distension and less foodintake.