饮料饮用量与溃疡性结肠炎发病风险相关性的Meta分析

摘要

Objective To evaluate the association between beverage consumption and the risk of ulcerative colitis (UC).Methods A comprehensive search was performed in PubMed, Embase and Cochrane Library databases to identify all relevant studies.Results A total of 13 studies involving 3 246 cases and 5 494 controls were included in this Meta-analysis. In pooled analysis of the highest vs the lowest categories,alcohol consumption was not associated with the risk of UC (RR=0.95,95% CI:0.72-1.26, I2=65.7%, n=6), but it was significant in Asian cohorts (OR=1.33,95% CI:1.05-1.69,I2=45.4%,n=3). Coffee consumption had a possible inverse association with the risk of UC (RR=0.58,95% CI:0.33-1.05, I2=87.5%, n=6). The consumption of soft drinks was associated with the risk of UC(RR=1.66,95% CI:1.27-2.19,I2=12.9%,n=5),especially in Caucasian cohorts(RR=1.84, 95% CI:1.32-2.57). Tea consumption had a reverse association with the risk of UC(RR=0.70,95% CI:0.58-0.84, I2=0, n =2) (Both of the included studies were Asian-cohorts-based). Conclusion This Meta-analysis indicated that increased consumption of soft drinks might be associated with the risk of UC,while increased consumption of tea might reduces the risk.%目的 评价溃疡性结肠炎(ulcerative colitis, UC)发病风险与饮料饮用量之间的关系.方法 在 PubMed、Embase 和Cochrane Library数据库上进行搜索获得所有相关的研究.结果 共纳入13个研究,包括3246例UC患者和5494例对照,综合分析显示,酒精性饮料的饮用量与UC发病风险无关 (RR=0.95,95% CI:0.72~1.26,I2=65.7%,n=6),但在亚洲人群亚组内呈显著正相关(RR=1.33,95% CI:1.05~1.69,I2=45.4%,n=3);咖啡的饮用量与UC的发病风险可能存在负相关(RR=0.58,95% CI:0.33~1.05,I2=87.5%,n=6);软饮料的饮用量与UC的发病率呈正相关(RR=1.66,95% CI:1.27~2.19,I2=12.9%,n=5),尤其在高加索人群中(RR=1.84,95% CI:1.32 ~2.57);茶的饮用量与UC的发病风险也呈负相关(RR= 0.70,95% CI:0.58~0.84,I2=0,n=2)(两项研究对象均为亚洲人群).结论 此次Meta分析提示,大量饮用软饮料可增加UC的发病风险,而多喝茶可降低此类风险.