目的：探究无创正压通气对慢性阻塞性肺疾病（COPD）合并呼吸衰竭患者的临床治疗效果。方法随机选取本院2013年6月至2014年6月收治的100例COPD合并呼吸衰竭患者为研究对象，按照随机数表法将其分为试验组和对照组，每组各50例。两组患者均给予常规药物治疗，试验组患者在此基础上加用无创正压通气，观察比较两组患者肺通气指标[第一秒用力呼气容积（FEV1）、肺活量为25%时的呼气流速（PEF25）、肺活量为50%时的呼气流速（PEF50）、肺总容量（TLC）]，肺换气指标[肺一氧化碳弥散功能（DLco）、最大吸气压（PImax）、最大呼气压（PEmax）、氧分压（PO2）]和氧代谢指标[混合静脉血氧饱和度（SvO2）、动脉血氧含量（CaO2）、氧摄取率（ERO2）、耗氧量（VO2）]变化。结果治疗后3天，试验组患者FEV1、PEF25、PEF50、TLC均高于对照组（t1＝10.58，t2＝4.44，t3＝4.83，t4＝13.38），DLco、PImax、PEmax、PO2高于对照组（t1＝4.46，t2＝5.09，t3＝5.28，t4＝6.19），SvO2、CaO2、ERO2、VO2亦高于对照组（t1＝4.13，t2＝8.45，t3＝6.04，t4＝6.95），差异均具有显著性（P＜0.05）。结论使用无创正压通气治疗COPD合并呼吸衰竭效果良好，可有效缓解患者呼吸困难，提高其通气功能，值得临床进一步推广。%Objective To research noninvasive positive pressure ventilation for treatment of chronic obstructive pulmonary disease (COPD) complicating respiratory failure. Method Selected 100 cases of COPD complicating respiratory failure patients in our hospital from June 2013 to June 2014 as objects, they were randomly divided into experimental group and control group, 50 cases in each group. The two groups were given conventional therapy, experimental group used noninvasive positive pressure ventilation based on control group, pulmonary ventilation indexs and oxygen metabolism indexes (FEV1, PEF25, PEF50, TLC, DLco, PImax, PEmax, PO2, SvO2, CaO2, ERO2, VO2) of the two groups were observed. Result 3 days after treatment, FEV1, PEF25, PEF50, TLC of experimental group were higher than that of control group (t1=10.58, t2=4.44, t3=4.83, t4=13.38), DLco, PImax, PEmax, PO2 were higher than that of control group (t1=4.46, t2=5.09, t3=5.28, t4=6.19), SvO2, CaO2, ERO2, VO2 were higher than that of control group (t1=4.13, t2=8.45, t3=6.04, t4=6.95), the differences were statistically signiifcance (P < 0.05). Conclusion The use of noninvasive positive pressure ventilation for the treatment of COPD complicating respiratory failure can effectively relieve dyspnea, help patients improve ventilation function, is worthy of further promotion.
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