卵巢早衰患者血清白介素-1、淋巴细胞亚群的水平及临床意义

摘要

Objective: To explore the immune pathogenesis of premature ovarian failure (POF) by evaluating serum interleu-kin-lα (IL-lα ) , interleukin -1 α (IL-lα ) and lymphocyte subsets concentrations. Methods; Thirty women with POF were recruited as the study group, and 30 healthy women with regular menstrual cycle and normal ovulation served as the control group. The serum IL-lα, IL - 1 β, lymphocyte subsets concentrations were evaluated. Results; There was no significant difference in serum IL-la concentration between the two groups (P >0. 05) , and IL - 1(3 level in the study group was significantly lower than that of the control group ( P < 0. 05). There were no significant differences in the concentrations of T + B + NK, CD3 , CD4, CD8, CD4/CD8, CD19, CD16 + 56 between the two groups (P all > 0.05). Conclusion: The lower serum concentration of IL - 1 could imply autoimmune disorders in POF patients.%目的:通过测定卵巢早衰(POF)患者血清中白介素(IL) -1α、IL - 1β、淋巴细胞亚群(CD3、CD4、CD8、CD19、CD16 +56)的水平,探讨POF免疫致病机制.方法:调查时点内本中心就诊的POF患者30例为研究组；选取同期月经周期规律,尿黄体生成激素或B超监测有正常排卵,因男性因素或输卵管因素不孕妇女30例为对照组.比较两组妇女血清中上述指标的水平.结果:两组IL -1 α水平差异无统计学意义,但研究组IL - 1β水平低于对照组(P＜0.05)；两组T+B+NK、CD3、CD4、CD8、CD4/CD8、CD19、CD16+ 56水平均无差异(P均＞0.05).结论:POF患者血清中IL - 1β水平低于非POF妇女,可能提示POF患者存在自身免疫功能紊乱.