间苯三酚与硫酸镁治疗先兆流产临床效果的对比观察

摘要

Objective:To evaluate the clinical effectiveness of magnesium sulfate comparing to phloroglucinol for treating threatened abortion.Methods:From April 2014 to April 2016,one hundred and ten patients with threatened abortion in Hengdian Wenrong Hospital were included and randomly divided into the control group and the observation group (55 patients in each group).Patients in the control group were treated by magnesium sulfate alone,and patients in the observation group were given phloroglucinol alone.Clinical efficacy and adverse reactions of drugs were compared between the two groups.Results:The clinical effective rate (94.55％) and rate of preventing miscarriage (96.36％) of patients in the observation group were significant higher than those (65.45％ and 67.27％,respectively) of patients in the control group.Time of uterine contraction inhibition (2.12± 0.75 h) in the observation group was significant shorter than that in the control group (5.78 ± 1.31 h) (P＜0.05).Rate of neonatal mortality (1.82％) in observation group was significant lower than that (18.18％) in control group.The neonatal birth weight (2571.52 ± 231.09 g) and Apgar score (9.53 ± 2.45 points) in the observation group were significant higher than those (2133.24 ± 167.45 g and 8.33 ± 2.87 points) in the control group.The incidence of adverse reaction (7.28％) in the observation group was significant lower than that (29.09％) in the control group (P＜0.05).Conclusion:Phloroglucinol injection has effective for treating patients with threatened abortion.It can inhibit uterine contractions of pregnant women,prolong the gestation time,prevent miscarriage,and increase the outcomes of newborns.%目的:评价先兆流产应用硫酸镁和间苯三酚治疗的临床效果.方法:选取2014年4月-2016年4月在本院就诊的110例先兆流产患者,应用随机数字表法将其分为对照、观察两组各55例,对照组给予硫酸镁治疗,观察组给予间苯三酚治疗.比较两组临床疗效及对不良反应.结果:观察组临床有效率(94.6％)、保胎成功率(96.4％)均高于对照组(65.5％、67.3％);宫缩显效时间(2.1±0.8h)优于对照组(5.8±1.3h) (P＜0.05);新生儿死亡率(1.8％)低于对照组(18.2％),新生儿出生体重(2571.5±231.1g)及Apgar评分(9.5±2.5分)均高于对照组(2133.2±167.5g、8.3土2.9分)(P＜0.05);用药后不良反应发生率(7.3％)低于对照组(29.09％)(P＜0.05).结论:先兆流产患者应用间苯三酚注射液治疗的临床效果显著,可有效抑制孕妇宫缩,延长妊娠时间,保胎成功率较高,娩出新生儿情况良好,不良反应低.