应用激光扫描眼底镜录像血管造影测量眼血流指标

摘要

ObjectiveTo establish and evaluate the methods which can quantify the ocular hemodynamics by combined scanning laser ophthalmoscopy video fluorescein angiography with computerized digital image processing system．MethodsAfter acquiring serial digital images by video capture from some angiography videotapes and measuring the gray values of some fixed areas over time in these serial images，the gray value curves and some parameters were obtained．The inter- and intra-observer reproducibility surveys were carried out．ResultsThe hemodynamic parameters were obtained，which included sectional choroidal filling time and rate，sectional papillary filling time and rate，retinal arterial and venous filling time and rate，arterovenous passing time and diameter of artery and vein．The intra- and inter-observer reproducibility were fairly good．Conclusioncomputerized digital image processing system is useful for understanding retinal and choroidal circulation．%目的建立和评价应用激光扫描眼底镜录像血管造影和计算机视频图像处理技术定量了解眼血流动力学状况的方法。方法对青光眼病人进行激光扫描眼底镜荧光素、吲哚青绿视网膜脉络膜血管造影；利用计算机视频图像处理技术和相应的测量软件，测量视网膜脉络膜血管造影的系列数字化图像，得到相应的时间—荧光强度曲线，并计算该曲线得到反映血流动力学状况的指标。结果该方法可测量脉络膜分区的充盈时间及速率、视乳头分区的充盈时间及速率、视网膜动静脉充盈时间及速率、动静脉通过时间及动静脉血管直径。该方法的观察者间及观察者内的重复性良好。结论计算机视频图像处理技术可以有助于定量了解视网膜脉络膜血流动力学状况。