激素联合伐昔洛韦治疗带状疱疹疗效观察

摘要

目的 探讨皮内注射甲基强的松龙联合口服伐昔洛韦治疗带状疱疹疗效.方法 60例带状疱疹患者随机分为皮内注射甲基强的松龙、联合口服伐昔洛韦组(A组,n =30);口服伐昔洛韦组(B组,n=30).治疗后随访,对比分析两组疱疹、疼痛评价指标、带状疱疹后遗痛发生率、综合疗效方面差异.结果 两组患者基线特征相似.A组止疱时间、结痂时间、疼痛强度、疼痛缓解时间短于B组.30天随访,A组带状疱疹后遗神经痛发生率低于B组,60天、90天随访差异无统计学意义.综合疗效比较,A组总有效率为86.7％,B组总有效率为63.3％,A组优于B组.结论 皮内注射甲基强的松龙联合口服伐昔洛韦治疗带状疱疹效果优于单用伐昔洛韦治疗,能够缩短病程,降低带状疱疹后遗神经痛的发生.%Objective To investigate the clinical efficacy of oral valaciclovir plus intradermal injection of methylprednisolone for the treatment of herpes zoster patients.Methods Sixty herpes zoster patients were randomly divided into two groups as follow:Group A:30 patients received oral valaciclovir plus intradermal injection of methylprednisolone,and Group B:30 patients treated with oral valaciclovir.And the following indicators,including herpes evaluation index,pain rating index,the incidence of postherpetic neuralgia,and comprehensive therapeutic effect were compared between the two groups after treatment.Results The baseline characteristics were comparable between Group A and B.The time to cessation of new lesion formation,complete rash crusting,cessation of pain and pain intensity after the treatment in Group A were significantly superior to those in group B.And the incidence of postherpetic neuralgia in Group A was significantly lower than that of Group B at 30 days of follow-up.However,no significant difference was found between the two groups at 60 and 90 days of follow-up.Overall,the total clinical effective rate of Group A (86.7 ％) was better than Group B (63.3 ％).Conclusion The treatment of oral valaciclovir plus intradermal injection of methylprednisolone was superior to oral valaciclovir in improving the clinical symptoms of HZ patients and reducing the incidence of postherpetic neuralgia.