Sixty-six volunteers,including 24 subjects with normal glucose tolerance(NGT),18 patients with impaired glucose regulation (IGR),and 24 patients with type 2 diabetes mellitus ( T2DM ),underwent a test of continuous glucose monitoring.The data of continuous glucose monitoring were embedded into two-dimension Euclid space by Takens' embedding theory.Glycemic phase diagram was drawn by MATLAB.The area and center distance of glycemic phase diagram were calculated by computer.The distinction of glycemic variability and average glycemic level among different glucose regulation populations were analyzed.The results showed that there existed significant differences in body mass index,systolic blood pressure,diastolic blood pressure,low density lipoprotein-cholesterol,high density lipoprotein-cholesterol,triglyceride,total cholesterol,creatinine,and alanine aminotransferase among three groups( all P＜0.05 ).The levels of HbAIC,fasting plasma glucose( FPG ),postprandial 2 h plasma glucse (2hPG),area and center distance of glycemic phase diagram in T2DM group were higher than those in NGT and IGR groups( P＜0.01 ),and the levels of FPG,2hPG,area and center distance of glycemic phase diagram in IGR group were higher than those in NGT group( P＜0.01 ).The levels of FPG and 2hPG were correlated with area and center distance of glycemic phase diagram ( all P＜0.01 ).These results suggest that measuring the area and center distance of glycemic phase diagram is a good method to assess glycemic variability and average glycemic level during continuous glucose monitoring.%应用动态血糖监测系统对66名受试者[正常糖耐量(NGT)组24名、糖调节受损(IGR)组18例,2型糖尿病组24例]进行动态血糖监测,利用Takens嵌入理论将监测数据对应的时间序列嵌入到二维欧氏空间中,通过MATLAB数学软件绘制血糖相图,并计算相图面积及其中心距,分析不同糖调节人群的血糖波动和平均水平情况.结果显示,3组人群之间体重指数、收缩压、舒张压、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯、总胆固醇、肌酐和谷丙转氨酶的差异均有统计学意义(均P＜0.05)；2型糖尿病组的HbAIC、空腹血糖(FPG)、餐后2h血糖(2hPG)及血糖相图面积、相图中心距明显高于IGR和NGT组(均P＜0.01),IGR组的FPG、2hPG及血糖相图面积、相图中心距高于NGT组(均P＜0.01)；3组人群的FPG、2hPG均与血糖相图面积、相图中心距相关(均P＜0.01).这些结果提示血糖相图面积和中心距可以较好地反映受试者的血糖波动和平均水平情况.
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