目的：观察循环热灌注化疗对晚期胃癌合并腹腔积液患者的临床效果。方法选取2013年4月—2014年5月就诊的晚期胃癌合并腹腔积液患者110例作为研究对象，随机分为对照组（ n ＝56）和观察组（ n ＝54），对照组患者采用常规化疗，观察组患者采用循环热灌注化疗，对比分析2组患者的临床治疗效果、生活改善情况和不良反应发生率。结果观察组患者的总有效率明显高于对照组患者（78§．63％vs．55．36％， P ＜0．01），且观察组患者的生活质量改善率明显高于对照组患者（59．26％vs．37．50％， P ＜0．05）。对照组不良反应发生率为53．57（30／56），观察组为51．85％（28／54），2组比较差异无统计学意义（ P ＞0．05）。结论晚期胃癌合并腹腔积液患者采用循环热灌注化疗，能明显提高总有效率，在一定程度上改善患者的生活质量。%Objective To observe the effect of cyclic heat perfusion chemotherapy on patients with advanced gastric cancer with peritoneal effusion .Methods From 2013 April to 2014 May, 110 cases of patients with advanced gastric cancer with peritoneal effusion were enrolled as the research object , they were randomly divided into control group ( n =56) and ob-servation group ( n =54 ) , the control group was treated with conventional chemotherapy , patients in the observation group u-sing coelom continued circulatory hyperthermia perfusion .Clinical therapeutic effect , improvement of life , and the incidence of adverse reaction were compared between the 2 groups.Results The observation group’s total effective rate was significantly higher than that of the control group patients (78.63%vs.55.36%, P <0.01,) and the observation group patients life quali-ty improvement rate was significantly higher than that of patients in the control group (59.26%vs.37.50%, P <0.05).The control group ’ s incidence of adverse reaction was 53 .57% ( 30/56 ) , the observation group was 51 .85% ( 28/54 ) , the differences between the 2 groups revealed no statistical significance ( P >0.05).Conclusion Coelom continued circulatory hyperthermia perfusion for advanced gastric cancer patients complicated with ascites can significantly improve the total efficien -cy and the quality of life in certain extent .
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