目的：比较氨氯地平＋复方盐酸阿米洛利与氨氯地平＋复方盐酸阿米洛利＋通心络胶囊治疗高血压伴有左室肥厚（ LVH）患者的效果。方法将确诊的82例高血压伴LVH患者随机按数字表法以3∶2分为常规组（48例）和通心络组（34例）。常规组给予氨氯地辛＋复方盐阿米洛利；通心络组在常规组基础上加通心络。治疗6个月后，观察2组患者心脏结构、心功能及血压水平的变化情况。结果常规组及通心络组患者经过治疗后，收缩压（SBP）、舒张压（DBP）、室间隔厚度（IVST）、左室后壁厚度（LVPWT）、左室重量（LVM）、左室重量指数（LVMI）与治疗前比较，均有显著降低（ P ＜00．1）；E／A比值及LVEF 值与治疗前比较均有显著升高（ P ＜0．05）；2组间治疗后收缩压、舒张压差异无统计学意义（ P ＞0．05），但2组间IVST[（9．60±2．48）mm vs．（8．80±1．23）mm]、LVPWT[（9．39±1．20）mm vs．（8．07±1．40）mm]、LVM[（275．11±14．77）g vs．（271．02±16．25）g]、LVMI[（150．99±7．35）g／m2 vs．（147．02±8．88）g／m2]、E／A（0．73±0．18 vs．0．78±0．24）、LVEF [（65．28±3．15）％vs．（66．32±3．12）％]比较差异均有统计学意义（ P ＜0．05），通心络组改善更明显。结论通心络胶囊联用氨氯地平＋复方盐酸阿米洛利具有提高左室射血分数、改善心功能，从而达到延缓和／或逆转左室肥厚的功效。%Objective To compare the therapeutic effect of amlodipine +compound amiloride hydrochloride and am-lodipine +compound amiloride +Tongxinluo capsule for treating of hypertension associated with left ventricular hypertrophy . Methods Eighty-two patients with LVH were divided into conventional group ( 48 cases) , and Tongxinluo group ( 34 ca-ses), they were given routine amlodipine +compound amiloride;Tongxinluo capsule group based on the conventional thera-py, also added Tongxinluo capsule(1.14g once ,three times a day).After 6 months of treatment, cardiac structure and heart function and changes in blood pressure levels in the two groups were observed .Resutl s After treatment , conventional group and Tongxinluo group patients’ systolic blood pressure (SBP), diastolic blood pressure (DBP), inter-ventricular septum thickness ( IVST ) , left ventricular wall thickness ( LVPWT ) , left ventricular weight ( LVM ) , left ventricular mass index (LVMI) were significantly decreased compared with before treatment ( P <0.01);E /A ratio and LVEF values?were sig-nificantly increased than before treatment ( P <0.05);after treatment, between the two groups, systolic blood pressure, di-astolic blood pressure’s difference were not statistically significant ( P >0.05), but IVST [(9.60 ±2.48) min vs.(8.80 ± 1.23) min],LVPWT [(9.39 ±1.20) min vs.(8.07 ±1.40) min],LVM [(275.11 ±14.77) g vs.(271.02 ±16.25) g],LVMI[( 1509.9 ±7 .35) g /m2 vs.(147.02 ±8.88) g/m2 ],E/A (0.75 ±0.18 vs.0.78 ±0.24), LVEF [(65.28 ± 3.15)%vs .(66.32 ±3.12)%]’ s differences in the 2 groups were statistically significant ( P <0.05 ), the Tongxinluo group improved more obviously .Conclusion Tongxinl uo capsule combined with amlodipine +compound amiloride hydro-chloride can increase left ventricular ejection fraction , improving heart function , so as to delay ando/r reverse left ventricular hypertrophy .
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