男性糖尿病患者睾酮水平变化与氧化应激的关系

摘要

Objective To observe the influencing factors of serum total testosterone (TT ) and relationship between the serum TT and oxidative stress in male patients with T2DM. Methods 108 male patients with T2DM were enrolled. FPG ,blood lipid ,HbA1c ,insulin ,serum TT ,serum malondialdehyde (MDA) and superoxide dismutase (SOD) were detected. According the TT level ,subjects were divided intotertiles(the lowest tertile‐tertile1 ,the middle tertile‐tertile2 and the highest tertile‐tertie3). Results Compared with tertile1 ,the levels of age ,BMI ,DBP ,HbA1 c ,TG ,MDA and SOD were significantly different for tertile3(P<0.05) and the levels of age ,BMI ,DBP ,HbA1 c ,TG and SOD were significantly different for tertile2(P<0.05). TT had negative correlation with HOMA‐IR(r= -0.576 ,P<0.01). TT had independent negative correlation with TG(β= -0.937 ,P<0.01) . Conclusion BMI ,DBP ,HbA1 c and TG are risk factors for TT reduction. TT is negatively correlated with HOMA‐IR. Enhanced oxidative stress levels may play an important role in the pathogenesis of TT reduction in male patients with T 2D M.%目的：观察影响男性糖尿病患者血清总睾酮（T T ）水平改变的因素及其水平改变与氧化应激（OS）的关系。方法选取男性T2DM患者108例，测定血清TT水平进行三分位法分组，按数值从低到高分为Tertile1（6.07～12.0 nmol／L）组，Tertile2（12.20～15.37 nmol／L）组及Tertile3（17.14～21.36 nmol／L）组，各36例。检测各组FPG、血脂、HbA1c、胰岛素、血清丙二醛（MDA）和超氧化物歧化酶（SOD）。结果与 Tertile1组比较，Tertile2组和 Tertile3组年龄、BMI、DBP、HbA1 c、TG均降低，而 Tertile2组SOD升高，Tertile3组MDA降低，SOD升高（P＜0.05）。Pearson相关分析显示，TT 与 HOMA‐IR呈负相关（ r＝－0.576，P＜0.01）。多元逐步回归分析显示，T T与T G呈独立负相关（β＝－0.937，P＜0.01）。结论高水平 TT 组年龄、BMI、DBP、TG、HbA1 c及 MDA降低，SOD升高。 TT 与 HOMA‐IR呈负相关，TT与TG呈独立负相关。