目的 探讨0.05％丙酸氟替卡松乳膏和青鹏软膏序贯疗法治疗慢性湿疹的临床疗效.方法 将91例患者随机分为3组,序贯疗法组30例给予丙酸氟替卡松乳膏和青鹏软膏序贯治疗,对照组Ⅰ组32例单用丙酸氟替卡松乳膏,对照Ⅱ组29例单用青鹏软膏.3组患者在治疗2周及4周后评判疗效.结果 治疗2周后,序贯疗法组与对照Ⅰ组、对照Ⅱ组疗效比较差异均有统计学意义(对照Ⅰ组P＜0.05,对照Ⅱ组P＜0.01).治疗4周后,序贯疗法组与对照Ⅰ组疗效比较差异无统计学意义(P＞0.05)；与对照Ⅱ组疗效比较差异有统计学意义(P＜0.05).结论 丙酸氟替卡松乳膏和青鹏软膏序贯疗法治疗慢性湿疹起效快,疗效好,不良反应少,患者依从性强,值得临床应用.%Objective To observe the efficacy of sequential therapy of 0.05% fluticasone propionate cream combined with Qingpeng ointment in the treatment of chronic eczema. Methods 91 patients were randomly divided into three groups. 30 patients in sequential therapy group were sequentially treated with fluticasone propionate cream followed by Qingpeng ointment. 32 patients in control group Ⅰ were only treated with fluticasone propionate cream. 29 patients in control group Ⅱ were only treated with Qingpeng ointment. The clinical efficacy of these three groups were evaluated at the second and fourth week after the treatment process. Results After two weeks' treatment, there was significant difference between the sequential therapy group and two control groups (control group Ⅰ P<0.05, control group Ⅱ P<0.01). After four weeks' treatment, there was no significant difference between sequential therapy group and control group Ⅰ (P>0.05), and there was significant difference between sequential therapy group and control group Ⅱ (P<0.05). Conclusion The efficacy of sequential therapy of fluticasone propionate cream combined with Qingpeng ointment in the treatment of chronic eczema has rapid and better response and less adverse reactions. And the patients compliance is good. Therefore it is worthwhile to be clinical applied more extensively.
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