光动力联合二氧化碳激光治疗顽固性跖疣的研究

摘要

Objective To observe the clinical effect of topical 5-ALA photodynamic therapy (PDT) combined with carbon dioxide laser for the treatment of recalcitrant plantar warts. Methods 30 patients with recalcitrant plantar warts were collected, removed the thick and hard stratum corneum, sealed with 20% 5-ALA cream for four to five hours, irradiated with 633 nm red light for 20 minutes (126 J/cm2), and human papillomavims (HPV) genotyping by polymerase chain reaction (PCH )method. Results After three times of photodynamic therapy, 16 patients had a complete regression(533%), four patients had partial regression (13.3%), and 10 patients had no response (333%), No statistical significance was found in different phenotypes of HPV. Conclusion Topical 5 -ALA PDT combined with carbon dioxide laser for the treatment of recalcitrant plantar warts is a new, effective and safe method. It might be another choice of treatment method for recalcitrant plantar warts.%目的 观察外用5-氨基酮戊酸(5-ALA)光动力联合二氧化碳(C02)激光治疗顽固性跖疣的临床疗效.方法 收集顽固性跖疣患者30例,超脉冲C02激光去除厚硬的角质层,20％ 5-ALA霜封包4～5 h,633 nm的红光照射20 min( 126 J/cm2),用聚合酶链反应技术(polymerase chain reaction,PCR)技术进行人乳头瘤病毒(humanpapillomavirus,HPV)病毒分型,分析各型HPV对光动力治疗反应的差异.结果 本组30例患者经3次光动力治疗,16例患者完全缓解(完全缓解率53.3％),4例(13.3％)患者部分缓解,10例(33.3％)患者无反应.各型HPV对光动力治疗的反应差异无统计学意义.结论 外用5-ALA光动力联合二氧化碳激光治疗顽固性跖疣是一种新的、有效的、安全的治疗方案,可以作为跖疣的二线治疗方案.