窄谱中波紫外线对银屑病Th17/Treg表达的影响

摘要

Objective To study the impact of expression level of Th17/Treg in patients with psoriasis vulgaris who received the narrow-band ultraviolet B (NB-UVB) therapy,and to explore the mechanism of ultraviolet therapy in psoriasis with NB-UVB.Methods 61 patients were only treated with NB-UVB radiation.Th17 and CD4+CD25+Treg were measured by flow cytometric analysis after 10 times and 20 times in patients who were treated with NB-UVB radiation.50 heahhy people were enrolled as control.Results Th17/Treg in patients was higher than that in normal controls.After treatment with NB-UVB,Th 17/Treg expression was decreased (P＜0.01).Conclusion Radiation of NB-UVB works well on Th 17/Treg in patients,and it may take effect through the cell immunity.%目的 研究窄谱中波紫外线(NB-UVB)治疗寻常性银屑病的临床疗效以及对患者Th17/Treg的影响,探讨NB-UVB治疗寻常性银屑病的机制.方法 61例寻常性银屑病患者采用NB-UVB光疗.采用流式细胞技术分别于光疗前、光疗10次后、光疗20次后检测患者Th17细胞和CD4+CD25+Treg细胞亚群的表达;同时检测50例健康人员Th17、CD4+CD25+Treg水平作为对照组.结果 寻常性银屑病患者Th 17/Treg明显高于正常对照组,患者光疗10次、20次后均得到明显改善(P＜0.01).结论 NB-UVB可有效降低银屑病Th17/Treg表达,这可能是NB-UVB治疗银屑病免疫学机制之一.