颅底骨缺损硬脑膜膨出的实验研究

摘要

目的：建立颅底缺损硬脑膜膨出量评估公式，为临床颅底缺损重建提供科学实验依据。方法：通过力学蠕变挠度分析，得到预计硬脑膜膨出量的力学计算公式，设计相应的力学模拟实验和动物实验加以验证。结果：力学模拟实验及动物实验证明通过力学分析得到的公式是基本正确的。结论：我们建立的颅底骨缺损硬脑膜膨出量评估公式，可以用来预测硬脑膜及其替代物膨出量的动态变化。%Aim:To establish the biomechanical assessment formula that predicts protrusion ofthe dura mater at the cranial base bone defect, and provide scientific experimental basis for cranial base defect reconstruction. Methods: The biomeehanical formula is established by using the creep reflecton analysis and validated by the simulated test and animal expeximents. Results: The simulated test and animal experiments reveal that biomechanical formula is right. Conclusion: The biomechanical formula can be used to predict the dynamic change of protrusion of the dura mater as well as its substitutes at different sizes of cranial base bone defects.