成人隐匿性自身免疫糖尿病与2型糖尿病血管并发症对比分析

摘要

目的：比较成人隐匿性自身免疫糖尿病（LADA）与2型糖尿病（T2DM）的临床及代谢特征，探讨两者微血管和大血管并发症的差异。方法比较48例 LADA 患者与55例 T2DM患者的血压、血脂、体质量指数、空腹血糖、糖化血红蛋白（HbA1 c）、C 肽、颈部血管及下肢血管 B 超检查结果、眼底检查、尿微量白蛋白的差异。结果入院时 LADA 组与 T2DM组相比较，在体质量指数、血压、血脂、C 肽释放水平低（P ＜0．05）；在脑梗死、颈部和下肢血管斑块的患病率上，LADA 组较 T2DM组低（P ＜0．05）；两组在糖尿病肾病、糖尿病视网膜病变的患病率差异无统计学意义（P ＞0．05）。结论LADA 患者在早期即出现血管并发症，与 T2DM相比，LADA在微血管病变比大血管病变更严重。%Objective This study aimed to assess the clinical characteristics and the prevalence of microvascu-lar and macrovascular complications in latent autoimmune diabetes in adults (LADA)and type 2 diabetes (T2DM). Methods Blood pressure,lipids,body mass index (BMI),fasting plasma glucose,glycosylated hemoglobin,C peptide, neck blood vessels and lower extremity arteries B ultrasound,fundus examination as well as urine micro albumin were compared.Between 48 patients with LADA and 55 patients with type 2 diabetes.Results Compared patients with T2DM,patients with LADA was at a lower level in BMI,blood pressure,lipids and C peptide release (P <0.05).LADA patients had lower prevalence of Cerebral infarction,neck and lower extremity vascular plaque (P <0.05).Similar prev-alence of diabetic nephropathy and diabetic retinopathy (P >0.05)were found between LADA patients and T2DM. Conclusion LADA patients show vascular complications in the early stage.Compared with T2DM,LADA has a higher prevalence of microvascular complications than macrovascular complications.