Photocatalyzed Reverse Polarity Oxidative Povarov Reaction of Glycine Derivatives with Maleimides

摘要

An oxidative tandem (4+2)-cyclization/aromatization of N-aryl glycine derivatives with electron-deficient alkenes was first achieved using Ru(bpy)3Cl2 as a photocatalyst and TBHP as an oxidant in combination with visible-light irradiation by blue LEDs.One-electron oxidation and the following α-deprotonation of glycine derivatives afford α-amino alkyl radicals,which were then trapped by elec-trophilic maleimides.As an atom-economic and efficient method,a variety of pyrrolo[3,4-c]quinoline-1,3-diones have been obtained in good yields under mild reaction conditions.