Natural biopolymer-based hydrogels have been extensively studied in recent years due to their excellent biocompatibility.However,the preparation of multi-functional and tough natural biopolymer-based hydrogels is still a challenging problem.Herein,a natural bi-opolymer-based hydrogel is prepared using gelatin and carboxymethyl chitosan (CMCS) through a one-step soaking method.The prepared hydrogel without any synthetic polymers and crosslinking agents has a fully physical crosslinking structure.Due to the hy-drophobic interaction brought by the Hofmeister effect,the mechanical properties of soaked hydrogels (tensile stress and strain can reach 3.77 MPa and 1082%) are superior to conventional protein hydrogels.In addition,the prepared gelatin/carboxymethyl chitosan(Gel/CMCS) hydrogels exhibit a variety of appealing properties,including good shape memory,fatigue resistance,electrical conduc-tivity,water retention,drug releasing,antibacterial property,and recyclability.This strategy opens up a new horizon to fabricate hy-drogels with excellent mechanical properties and multiple functions,which can extend their applications in the biomedicine area and other related fields.
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