Summary of main observation and conclusion A new and intriguing methodology to access various O-difluoromethylation oxime compounds from ClCF2H,TBN and indoles is developed under mild reaction conditions.This strategy can suppress N-difluoromethylation of indoles successfully,in which there are two different active species (:CF2 and ·NO) while indoles are unprotected,featuring simple operation and radical involvement.
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