Study of the Interaction of Cephalosporin Class Medicine with Albumin by Fluorescence Enhancement and Fluorescence Quenching Theories

摘要

The interaction of 7 kinds of cephalosporin-medicine with HSA and BSA was studied and compared using fluorescence enhancement and fluorescence quenching method, then deeply analyzed. The binding characteristics of medicine with albumin and usual characteristic constants such as dissociation constant, quenching constant,quenching efficiency, energy-transfer efficiency and the distance between donor and accepter were also deeply analyzed.