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《中国化学:英文版》
>KAI(SO4)2-12H2O (Alum) Catalyzed One-Pot Three-Component Synthesis of 2-Alkyl and 2-Aryl-4(3H)-quinazolinone under Microwave Irradiation and Solvent Free Conditions
KAI(SO4)2-12H2O (Alum) Catalyzed One-Pot Three-Component Synthesis of 2-Alkyl and 2-Aryl-4(3H)-quinazolinone under Microwave Irradiation and Solvent Free Conditions
Twenty 2,3-disubstituted-4(3H)-quinazolinones were synthesed by one-pot three-component method with isa- toic anhydride, orthoesters and amines as raw materials in the presence of KAI(SO4)2·12H2O (Alum) under micro- wave irradiation and solvent-free conditions. 6-Bromo-2-propyl-3-p-tolylquinazolin-4(3H)-one (4m), 6-bromo-2- methyl-3-phenethylquinazolin-4(3H)-one (4n) and 6-bromo-2-ethyl-3-phenethylquinazolin-4(3H)-one (40) were characterized by IR, 1H NMR, 13C NMR and elemental analysis.
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