Spectrophotometric Determination of Albendazole Drug in Tablets: Spectroscopic Characterization of the Charge-transfer Solid Complexes

摘要

Simple,rapid and reliable method for the determination of albendazole(ABZ)was described.This includes the utility of some π-acceptors such as 2,3-dichloro-5,6-dicyano-p-benzoquinone(DDQ)and 3,6-dichloro-2,5-dilaydroxy-p-benzoquinone(p-CLA)for estimation of ABZ drug(act as donor).The experimental conditions were optimized and the system obeys Beer's law for 7.50-80 and 10.00-85.00 μg-mL-1 of ABZ using DDQ and p-CLA,respectively.The molar absorptivity and Sandell sensitivity were calculated to be 1.83× 103 and 1.12X 103 L·mol-1·ocm-1,and 2.60 and 3.40 ng.cm-2 using DDQ and p-CLA,respectively.The limits of detection and quantification were calculated to be(7.42 and 6.73)and(9.94 and 4.13)μg·mL-1 using DDQ and p-CLA,respectively.The proposed methods were successfully applied to the determination of ABZ in commercially available dosage forms.The reliability of the assays was established by parallel determination by the official method and recovery studies.The chemical structures of the solid charge-transfer(CT)complexes formed via reaction between ABZ under study and π-acceptors,have been elucidated using elemental analyses(C,H and N),IR,1H NMR and mass spectra.